Wellbutrin vs Zoloft – Which is better for anxiety?

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Wellbutrin vs Zoloft - which is better for anxiety


It's the brand of a medicine called bupropion, An antidepressant used to stop smoking and to treat a variety of conditions, such as anxiety disorder and depression.

This drug was first synthesized in 1966 by the group of scientists from Burroughs Research who were looking for a drug that would be active in the antidepressant detection models, but different pharmacologically and chemically from the tricyclics.

Even today, the exact mechanism of action of the medication is not exactly known, but it is known to increase dopaminergic and noradrenergic neurotransmission through the inhibition of the reuptake of the dopamine transporter and the norepinephrine transporter.


It is usually used to treat depression because it can improve feelings of well-being. In addition, it is occasionally used to treat the symptoms of impulsivity and hyperactivity in people with attention deficit hyperactivity disorder (and the symptoms of depression that can coexist with ADHD) when traditional medications are not effective.


It is available in sustained release formulas (100 and 150 mg) and immediate release (75 and 100 mg tablets).

When the patient begins taking this medication for the first time, the initial dose should be a maximum of 150 mg per day. This dose is gradually increased to reduce the incidence of seizures.

Side effects and precautions

Common Side effects can include:

sleep problems (insomnia); changes in appetite, such as – weight loss or weight gain; dizziness; uneasy tremors; agitation; Confusion; vomiting nausea; migraines; Headaches

Rare side effects may include:

blurry vision; abdominal pain; Dry mouth constipation; change in the sense of taste; increased sweating; drowsiness; tremor or tremor; frequent need to urinate; irregular heartbeat; unusual feeling of well-being; Muscle pain; throat pain


It is recommended to avoid alcoholic beverages while taking this antidepressant.

Drug interactions

You can interact with the following medications:

Metropolol (Lopressor); Paroxetine (paxil); Ritonavir (an antiretroviral medicine); Sertraline (zoloft); Elfavirenz (Sustiva); Fluoxetine (prozac); Lopinavir (Kaletra); Diazepam (Valium); Venlafaxine (effexor); Clopidogrel (an antiplatelet medication); Phenytoin (dilantin); Ticlopidine (ticlid); Imipramine (tofranil); Orfenadrine (Norflex); Haloperidol (a typical antipsychotic medication); Carbamazepine (tegretol); Thioridazine (Sonapax); Clotrimazole (Canesten); Flecainide (tambocor); Rifampicin (rifadine); Propafenone (Rythmol); Phenobarbital (a medicine used to treat certain types of epilepsy); Risperidone (risperdol); Desipramine (norpramin); Nortriptyline (Pamelor); Caramazepinen (Carbatrol).

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It is the brand name of a medication called sertraline, an antidepressant that belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs).

Is the medication works By affecting the balance of chemicals in the brain. More precisely, it increases the level of serotonin, a neurotransmitter in the brain. Increased serotonin levels can help reduce panic attacks, improve mood and treat obsessive-compulsive disorder.

By 2005, it was reported to be the most popular selective serotonin reuptake inhibitor in the United States market and the sixth most prescribed prescription drug, with around $ 2.6 billion in sales.

The US Food and Drug Administration UU It was approved for the first time in 1999. The drug is marketed by Pfizer, a US-based pharmaceutical corporation based in New York City.


It is usually used to treat obsessive-compulsive disorder, depression, social anxiety disorder (social phobia), panic disorder, post-traumatic stress disorder and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).


The usual recommended dose for premenstrual dysphoric disorder is 50 to 150 mg per day of the menstrual cycle or for 2 weeks before menstruation. The usual recommended dose for panic disorder varies from 25 mg to 200 mg once a day.

The normal recommended dose for the treatment of depression and social anxiety disorder starts at 25-50 mg once a day. This initial dose may be increased at weekly intervals until the symptoms improve. The maximum dose is 200 mg per day.

Note: the medicine should be taken with food, preferably at night. Children under 12 stay better away from the medication, as it can cause extreme side effects in them.

Side effects and precautions of sertraline

Common side effects may include:

feel anxious or agitated; fatigue; drowsiness; increased sweating, a condition known as diaphoresis; loss of appetite; Diarrhea; nausea; indigestion; dizziness; insomnia (sleep problems); nervousness; tremor headaches; abnormal ejaculation; decreased interest in sexual activity; acne; irregular heartbeats; constipation; unexplained weight loss; Stomach ache; dry mouth.

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Rare side effects may include:

worsening of depression; abnormal bleeding decreased liver function; hyponatremia; serotonin syndrome; shake; thoughts about suicide; activation of mania in patients with bipolar disorder; priapism (prolonged erection); difficulty having an orgasm; impotence; pain or swelling in the eyes memory problems; a seizure (convulsions); feel unstable tunnel vision; blurry vision; be irritable or talkative; severe weakness; Extreme happiness; Confusion; unusual risk behavior; increase in energy.

To make sure this medication is safe for you, tell your health care provider if you have ever had:

a seizure; kidney disease; a hit; bleeding problems; high blood pressure; liver disease; bipolar disorder (manic depression); heart disease; low levels of sodium in your blood; If you take warfarin (Jantoven, Coumadin).

Pregnancy and lactation

Pregnancy and breastfeeding are two conditions in which anti-anxiety medications should be used sparingly or avoided altogether.


If you stop taking this medication suddenly, you may experience withdrawal symptoms such as tremors, nausea, muscle aches, lightheadedness, insomnia, weakness and anxiety.

To avoid these unpleasant symptoms, your health professional will slowly reduce your dose when you stop taking the medication.

Drug interactions

Do not take this medication if you have used a monoamine oxidase inhibitor, such as – isocarboxazid (Marplan), furazolidone (Furoxone), rasagilina (Azilect), phenelzine (Nardil), tranylcypromine (Parnate), or selegiline (Emsam, Eldepryl, Zelapar) in the last 2 weeks. A potentially fatal drug interaction could occur.

Wellbutrin vs Zoloft – Which is better for anxiety?

According to some studies, it was discovered that bupropion is equally effective as Zoloft in treating depression. However, bupropion has not been studied as a treatment for anxiety, therefore, it has not been recommended as a treatment for anxiety alone.

If you use Zoloft for anxiety disorder, do not expect it to help reduce your symptoms immediately. In general, you can see improvements within 7 to 14 days. However, it may take a few months before it reaches the full effects of the medication.


Wellbutrin vs Zoloft: What is better for anxiety? Source: https://www.yourhealthremedy.com/health-tips/wellbutrin-vs-zoloft/

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