It is the mark of a drug called plecanatide that acts by activating certain substances (such as the enzyme guanylate cyclase-C) in the intestines that help increase muscle movement and fluid secretion.
Is the drug was approved for the first time by the United States Food and Drug Administration in January 2017.
It is usually used for the treatment of chronic idiopathic constipation. "Chronic" means that signs and symptoms often occur over a long period of time and "idiopathic" means that constipation can not be attributed to an underlying disease or medication and is due to an unknown cause.
Chronic idiopathic constipation is a common condition and affects more than 35 million American adults. The main signs and symptoms of chronic idiopathic constipation include:
tight; infrequent bowel movements; swelling hard stools; gas pain; abdominal pain; feeling that something is preventing the stool from coming out; A feeling of incomplete evacuation.
The usual recommended dose is 3 mg orally once a day. Due to the risk of severe dehydration, this medication should not be used in children under 6 years of age.
In addition, it can be crushed in applesauce for people who can not swallow the medication.
Side effects and precautions of Plecanatide
Sinus infection; Diarrhea; dehydration; increase in biochemical tests of the liver; colic pain abdominal sensitivity; gas; nausea swelling; headaches intestinal discomfort upper respiratory tract infection.
To make sure this medication is good for you, tell your healthcare professional:
about all medications you take, including herbal supplements, over-the-counter medications and prescription medications and vitamins; if you are breast-feeding because it is not known exactly if this medicine passes into breast milk; if you are pregnant or plan to become pregnant, since it is not known with precision if this medicine will harm your baby before birth; If you have any other medical condition.
You may interact negatively with other medications, especially:
idelalisib; Zydelig (idelalisib).
Is the brand of a medicine called linaclotide that acts by binding and activating some enzymes in the intestines, accelerating the movement of the contents through the intestines. It belongs to a group of medicines called guanylate cyclase agonists-C (GC-C).
This medication was approved for the first time by the US Food and Drug Administration. UU In August 2012. It is manufactured by Ironwood Pharmaceuticals, a pharmaceutical company that develops drugs for cardiovascular and gastrointestinal diseases.
It is a prescription medication that is generally used in adults to treat irritable bowel syndrome with constipation and chronic idiopathic constipation.
The usual recommended dose to treat chronic idiopathic constipation is 145 mcg once a day. The usual recommended dose for treating irritable bowel syndrome with constipation is 290 mcg once a day.
In addition, it is suggested to take this medication on an empty stomach, at least half an hour before the first meal of the day. Because it can cause severe diarrhea and severe dehydration, do not administer medication to children under 6 years of age.
Side effects and precautions of linaclotide
Common side effects may include:
Diarrhea; swelling; abdominal discomfort; sinusitis pain; sneezing congested nose headaches a feeling of fullness in your stomach; vomiting acidity; gas.
Rare side effects It can include:
a feeling of dizziness as if he could faint; severe diarrhea; severe stomach pain; black, bloody or tarry stools; muscular weakness; fluttering in the chest; irregular heartbeats; feel unstable Confusion; humor changes; leg cramps; Increased thirst or urination.
If you use this medicine during breast-feeding, talk with your healthcare provider about possible risk factors, since there are no conclusive clinical studies showing that this medicine is not passed on to breast milk.
Also, consult your health care provider and discuss the benefits and risks of using this medication while you are pregnant because there are no conclusive studies proving your safety during pregnancy.
Trulance vs Linzess – Differences
Trulance (active ingredient – plecanatide) is an agonist of guanylate cyclase-C, which is used to treat chronic idiopathic constipation. This medication works by increasing the fluid in the intestines and helping to accelerate the movement of food through the intestine.
Linzess (active ingredient – linaclotide) is a prescription medication used to treat chronic idiopathic constipation in adults. It works by increasing the amount of fluid in the intestine and making the contents move faster and easier. It is also part of a family of drugs called guanylate cyclase-C (GC-C).
In conclusion, both drugs are part of the same family of drugs and have similar effects in the human body, but they have different main active ingredients. Both have many side effects and do not treat the true cause of constipation, an unhealthy lifestyle.
5 natural home remedies to relieve constipation quickly
# one Magnesium
It is an essential mineral that helps move fluid through the large intestine, which greatly facilitates the expulsion of feces from the body.
If you want to take a magnesium supplement, magnesium citrate It is the form of magnesium that is absorbed more easily and has a stronger effect on the intestines.
However, the best source of magnesium is from food. Foods rich in magnesium include: pumpkin seeds, sesame seeds, red beans, chickpeas, lentils, kidney beans, pinto beans, pistachios, Brazil nuts, cashews, almonds, nuts, broccoli, pine nuts, oat bran, oats and nuts .
# 2 Increase your fluid intake
One of the main causes of constipation is dehydration because, in order for waste to move through your gastrointestinal tract, a lot of water is needed.
# 3 Blackstrap molasses
Image credit: https://commons.wikimedia.org/wiki/File:Blackstrapmolasses.JPG
It contains high doses of potassium and magnesium, which are two potent contenders in the battle against constipation.
Exercise # 4
Lack of physical exercise could slow down the metabolism. And this could slow down digestion that can, ultimately, lead to constipation.
# 5 nutrition
Eating an unbalanced diet high in dairy products, eggs and meats (all give zero dietary fiber) can easily cause constipation.
To treat and prevent constipation, the most effective weapon is a regular diet with high fiber content. Try at least 50 grams of dietary fiber per day.
Foods rich in fiber include: sweet potatoes, carrots, cabbage, Brussels sprouts, garlic, onion, potatoes, corn, oat bran, oats, red beans, pinto beans, nuts, flax seeds, chia seeds, sunflower seeds , sesame seeds, almonds, pistachios, prunes, apples, pears, papayas, mangoes and pineapples.
Trulance vs Linzess – Uses, doses, side effects, differences, Source: https://www.yourhealthremedy.com/health-tips/trulance-vs-linzess/
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