Side effects and health benefits of L-citrulline

Filed in: Nutrients.

Side effects and health benefits of L-citrulline

L-citrulline is a non-essential amino acid, which means that you do not have to obtain it from food because the body can produce it as needed. It is manufactured by a variety of other amino acids in the liver.

Its name comes from the Latin word "citrullus" (watermelon), which is a Natural source from that Other sources of food include soybeans, pumpkins, pumpkins, cucumbers, peanuts and beans.

The role of L-citrulline in the body and health benefits

Urea cycle – this amino acid plays a key role in the urea cycle, which is the process by which the body eliminates the toxic byproducts of protein digestion and the generation of cellular energy.

Improves athletic performance – Bodybuilders and some other athletes use it to improve athletic performance and to prolong endurance during aerobic and anaerobic exercise sessions.

Improves blood flow – It does so by creating NO – nitric oxide, an important chemical for the health of the heart and blood vessels. Excess citrulline, according to numerous studies, increases the amount of arginine in the blood, which leads to an increase in the production of nitric oxide. Arginine works well for heart health and helps maintain a healthy immune system. In addition, arginine removes toxicities from the physical body such as ammonia and helps prevent obesity and type 2 diabetes from becoming problems.

In addition, more nitric oxide means greater blood flow to the muscles during exercise, allowing them to last longer under pressure and produce larger muscle pumps for weightlifters.

Doctors sometimes prescribe supplements with this amino acid after heart surgery to prevent pulmonary hypertension. In those cases, they are administered intravenously.

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Erectile dysfunction – It can also help treat mild erectile dysfunction in men. While doctors believe that this amino acid is not acting as fast as erectile dysfunction drugs, such as Viagra, it still offers help and with some side effects.

Unlike Viagra, which can help some men get an erection 30 minutes after taking a pill, but will not do anything to correct the real problem, this supplement helps restore the health of the blood vessels in the penis, correcting the underlying cause of erectile dysfunction.

Atherosclerosis – Supplementation with substances that increase nitric oxide, L-arginine and L-citrulline, along with other antioxidantsIt has been shown to delay endothelial senescence despite high levels of glucose or a high-fat diet. This delay in endothelial senescence through the activation of NO and / or eNOS may have clinical utility in the treatment and prevention of atherosclerosis associated with diabetes and menopause and with aging.

Dosage

The dose for this amino acid generally ranges from 6 to 18 grams per day, and is commonly sold in the form of citrulline malate and comes in powder form. The suggested dose depends on the disease you are trying to prevent or treat, but it is usually used up to 9 grams per day, divided throughout the day.

L-citrulline side effects

Because it is created by the body, it is believed that the supplement is safe. Due to the fact that there is insufficient clinical data on the safety of the supplement in pregnant or lactating women, use for these groups is not advised.

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In addition, it may interact with some prescription medications, including certain medications used to treat cardiovascular diseases, hypertension and erectile dysfunction. By dilating blood vessels and increasing NO, the amino acid actually lowers blood pressure in general. While this may be beneficial for users with prehypertension, some people already have low blood pressure, and a greater reduction may be harmful.

References

http://www.biochemj.org/content/33/6/902

https://pubchem.ncbi.nlm.nih.gov/compound/833#x291

https://www.ncbi.nlm.nih.gov/pubmed?term=PMID%3A%2016798303

http://www.sciencedirect.com/science/article/pii/S0006291X14018178

Side effects and health benefits of L-Citrulline, Source: https://www.yourhealthremedy.com/nutrients/l-citrulline-side-effects-health-benefits/

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