Nucala vs Xolair – Comparison of uses and side effects

Filed in: Health Tips.

Nucala vs Xolair - Comparison of uses and side effects

Nucala

It is the brand name of a medicine called mepolizumab that belongs to the class of drugs called monoclonal antibodies.

Mechanism of action

It works by reducing eosinophils in the blood, a type of white blood cells that fight disease.

Applications

This prescription medication is used to treat asthma in patients older than 12 years.

Note – It's not a rescue medicine. This medication will not work fast enough to treat an asthma attack.

In addition, it is used to treat patients with eosinophilic granulomatosis with polyangiitis (a disorder that causes inflammation of the blood vessels).

It is not approved for use by people under 12 years of age.

Dosage

This medicine is given in the thigh, upper arm, or abdomen. The usual recommended dose is 100 mg subcutaneously every 4 weeks. The need for continuous therapy with this medication should be evaluated at least once a year.

Side effects

Common side effects may include:

burning or itching at the place where the medicine was injected; headache; Back pain; Feeling weak or tired

Rare side effects may include:

a red or blistering rash; unusual pain or tiredness; Burning anywhere in your body.

Precautions

Before taking this monoclonal antibody, tell your healthcare provider if you have:

never had chicken pox or received a varicella vaccine with a history of shingles; a history of parasitic infection; Use steroid medications for asthma.

Alcoholalcohol

Avoid drinking alcoholic beverages while taking this monoclonal antibody since alcohol consumption can substantially increase the risk of serious side effects.

Drug interactions

You may interact negatively with other medications, especially:

An oral or inhaled steroid medication.

Pregnancy and lactation

It is not known if this monoclonal antibody passes into breast milk or if it could harm a nursing infant. Tell your healthcare provider if you are breast-feeding a baby.

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It is not known if this monoclonal antibody will harm a developing fetus. Tell your health care provider if you are pregnant or planning to become pregnant.

Xolair

It is the brand name of a medication called omalizumab that belongs to a group of drugs called monoclonal antibodies.

Mechanism of action

It works by blocking the IgE antibody, the least abundant, but the most potent antibody classes found in the human body.

Applications

This prescription medication is used to reduce asthma attacks in patients with asthma caused by pollen, dandruff and dust mites.

Note: Do not give this medication to a child under 12 years of age.

Dosage

The usual recommended dose is 375 mg per subcutaneous injection every 2 or 4 weeks.

Side effects

Common side effects may include:

nausea; mild rash feeling of tiredness Itching; earache; bone fractures; dizziness; joint pain; sore throat; arm or leg pain; sinusitis pain.

Rare side effects may include:

fast or weak heartbeat; urticaria; difficulty breathing a feeling that you may faint; swelling of the face, lips, tongue or throat; anxiety; wheezing oppression in the chest; redness in one or both legs; muscular weakness; problems with vision or speech; coughing up blood; pain in the chest that extends to your jaw or shoulder; Inflamed glands.

Precautions

Before taking this monoclonal antibody, tell your healthcare provider if you have:

if you have ever had a severe allergic reaction (anaphylaxis); any sign of infection (inflamed glands, fever, general malaise); if you are receiving allergy shots; a history of heart attack; past or present cancer; an infection caused by parasites (such as hookworms, pinworms, giardia or toxoplasmosis).

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Alcohol

Avoid drinking alcoholic beverages while taking this monoclonal antibody since alcohol consumption can substantially increase the risk of serious side effects.

Drug interactions

Can interact negatively with another medicinesespecially

Echinacea; Vitamin E; Zinc (zinc sulfate).

Pregnancy and lactation

It is not known if this monoclonal antibody will harm a developing fetus. Tell your health care provider if you are pregnant or planning to become pregnant.

It is not known if this monoclonal antibody passes into breast milk or if it could harm a nursing infant. Tell your healthcare provider if you are breast-feeding a baby.

Bottom line – Nucala vs Xolair

Nucala (active ingredient – mepolizumab) is a monoclonal antibody used in conjunction with other medications to help control severe asthma in adults and children who are at least 12 years old. It works by reducing the levels of a certain type of white blood cell that can contribute to the symptoms of asthma.

Xolair (active ingredient – omalizumab) is an antibody used to treat moderate to severe asthma that is caused by allergies in adults and children who are at least 6 years old. It works by decreasing allergic responses in the body. This medication is not a rescue medication to treat an asthma attack.

According to a 2018 study, the efficacy of omalizumab and mepolizumab was similar in the treatment of asthma that was not well controlled with at least high doses of inhaled corticosteroids.

Referenceshttps://www.nejm.org/doi/full/10.1056/NEJMoa1403290https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60988-X/abstracthttps://www.ncbi.nlm.nih.gov/pubmed/28395936

Nucala vs Xolair – Comparison of uses and side effects, Source: https://www.yourhealthremedy.com/health-tips/nucala-vs-xolair/

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