Mesalamine vs Sulfasalazine – Comparison of uses and side effects

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Mesalamine vs Sulfasalazine - Comparison of uses and side effects

Mesalamine

It is the generic name of a medicine that belongs to a group of medicines called aminosalicylates. It can be found under the following brand names: Lialda, Asacol HD, Delzicol, Apriso and Pentasa.

Mechanism of action

It works by preventing the body from producing a certain substance that can cause inflammation or pain in the colon.

Applications

This prescription medication is used to treat ulcerative colitis, a long-term condition that causes inflammation and ulcers in the rectum and colon.

Dosage

The usual recommended dose is 1 g orally 4 times a day for up to 8 weeks. Take this medication with a full glass of water.

Side effects and precautions

Common side effects may include:

Back pain; constipation; eruption; Diarrhea; abnormal liver function tests; stomach ache; headache; sore throat; sinusitis pain; nausea; Runny or stuffy nose.

Rare side effects may include:

feeling tired or out of breath; bloody diarrhea; jaundice (yellowing of the skin or eyes); cramps loss of appetite; severe stomach pain; acne; clay-colored stools; fever; upper stomach pain; dark urine; swelling in the feet or ankles; painful or difficult urination; coughing up vomiting that looks like coffee beans; bruising or easy bleeding; little or no urination; Bloody or tarry stools.

Contraindications

Before taking this aminosalicylate, tell your healthcare provider if you have:

allergic or sensitive to salicylates; Allergic to mesalamine.

Alcohol

Avoid drinking alcoholic beverages while taking this aminosalicylate since the consumption of alcohol can substantially increase the risk of serious side effects.

Drug interactions

You may interact negatively with other medications, especially:

naproxen; aspirin; ibuprofen; Azathioprine; Low potency aspirin

Pregnancy and lactation

It is not clear what effect this aminosalicylate has on breastfed infants; Consult your health professional before taking the medication if you are breast-feeding a baby.

The effects of this medication on the developing fetus of a pregnant woman have not been studied. Talk to your health care provider about aminosalicylate if you are pregnant or planning a pregnancy.

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Sulfasalazine

It is the generic name of a medication that belongs to a class of medications called sulfa medications. It can be found under the following brand names: azulfidina or sulfazina.

Mechanism of action

This medicine works by affecting a substance in the human body that causes tissue damage, inflammation and diarrhea.

It is manufactured as bluefidine by Pfizer. The United States Food and Drug Administration originally approved this drug in 1950.

Applications

This prescription medicine is used to treat the symptoms of ulcerative colitis, such as diarrhea, intestinal inflammation, abdominal pain, and rectal bleeding.

Dosage

The usual recommended dose is 3 to 4 g per day orally in evenly divided doses.

Side effects

Common side effects may include:

feeling tired or out of breath; painful or difficult urination; severe nausea or vomiting; a red or purple skin rash that spreads and causes blistering and peeling; burning in your eyes; swelling of the face, feet, ankles or tongue; sore throat; little or no urination.

Rare side effects It can include:

Fainting; cold; fast and shallow breathing; sudden weakness or discomfort; high cardiac rhythm; difficulty breathing; jaundice (yellowing of the skin or eyes); sore throat; unusual bleeding; red or inflamed gums; wheezing bruises easily; skin sores; painful sores in the mouth; pain when swallowing; cough with yellow or green mucus; stabbing pain in the chest.

Precautions

Before taking this sulfa. rerug, tell your health care provider if you have:

thyroid problems; asthma; severe allergies or allergies to any type of medication; liver disease; kidney disease; an obstruction in your stomach or urinary tract; porphyria (a blood disorder); an infection that keeps coming back; anemia or low levels of white blood cells; a deficiency of glucose-6-phosphate dehydrogenase (G6PD); Rheumatoid arthritis.

Alcohol

Avoid consuming alcoholic beverages while taking this medication since alcohol consumption can substantially increase the risk of serious side effects.

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Drug interactions

You may interact negatively with other medications, especially:

naproxen; Aleve (naproxen); invega; methotrexate; aspirin; ibuprofen; diphenhydramine; Aspirin Low Strength; Celebrex (celecoxib); Nucala; folic acid.

Pregnancy and lactation

This sulfa drug can be found in breast milk. You should not breast-feed a baby while taking this medication without first talking with your healthcare provider.

The effects of this sulfa-based drug on the developing fetus of a pregnant woman have not been studied. Talk to your health care provider about the sulfa medication if you are pregnant or planning a pregnancy.

Conclusion – Mesalamine vs Sulfasalazine

Mesalamine (brand names: Lialda, Asacol HD, Delzicol, Apriso and Pentasa) is a medication used to treat mild to moderate ulcerative colitis. In addition, it is used to prevent the symptoms of ulcerative colitis from recurring. ¿¿¿¿¿¿¿¿!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! 30 Es ¿30 Es! 30 Es!!! 30 Es! 30 Es 30 Es 30 Es!!! 30 Es 30 30 30 Es 30 Es Es!!!!! 30 Es! 30 Es 30 Es 30 Es Es!!! 30 Es!!! 30 Es!

Sulfasalazine (brand names, bluefidine or sulfazine) is a medicine used to treat moderate to severe ulcerative colitis. In addition, it is used to treat rheumatoid arthritis in patients who have used other medications for arthritis without successful treatment of symptoms. ¿¿¿¿¿¿¿¿!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! 30 Es ¿30 Es! 30 Es!!! 30 Es! 30 Es 30 Es 30 Es!!! 30 Es 30 30 30 Es 30 Es Es!!!!! 30 Es! 30 Es 30 Es 30 Es Es!!! 30 Es!!! 30 Es!

According to a 2012 study, the haematological adverse effects of mesalazine treatment may be greater than those of sulfasalazine treatment.

With respect to its price, the average retail price of 120 tablets of mesalamine 1.2 g is $ 430, while the average retail price of 120 tablets of sulfasalazine 500 mg is $ 18.

Referenceshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314328/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108647/https://www.sciencedirect.com/topics/neuroscience/mesalazine

Mesalamine vs Sulfasalazine – Comparison of uses and side effects, Source: https://www.yourhealthremedy.com/health-tips/mesalamine-vs-sulfasalazine/

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