Guanfacine vs Intuniv – Comparison of uses and side effects

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Guanfacine vs Intuniv - Comparison of uses and side effects

Guanfacine

It is a sympatholytic medicine used to treat. hyperactive disorder and attention deficit (ADHD) and hypertension.

The drug belongs to a class of medications called centrally acting alpha2A adrenergic receptor agonists. It can be found under the following brands: Estulic, Tenex and Intuniv.

It works by affecting the activity of the brain chemical called norepinephrine. This neurotransmitter normally influences the heart rate, blood pressure and anxiety in the human body; however, norepinephrine also affects activation and attention.

Note – unlike other medications used to treat ADHD, this alpha2A-adrenergic receptor agonist is not a stimulant.

Applications

Is Medical prescription Used to treat high blood pressure. In addition, it is used to treat hyperactivity disorder, as part of a total treatment or a monotherapy plan that includes social, educational and psychological measures.

Attention deficit hyperactivity disorder is listed as a neurodevelopmental disorder in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders), the set of guidelines established by psychiatrists to diagnose mental illness.

Symptoms of ADHD

An estimated 1 in 20 children is diagnosed with ADHD at some time during their school life.

Young children usually tend to experience hyperactivity-impulsivity. As they begin elementary school, their symptoms may change to lack of attention. As teenagers, they usually become less hyperactive, however, they can struggle with feelings of inattentiveness, restlessness and impulsiveness.

Dosage

the recommended dose to treat the symptoms of attention deficit hyperactivity disorder is 1 to 4 mg per day.

Side effects Y Precautions

Common side effects may include:

dry mouth; constipation; drowsiness headaches; nausea; fatigue; weight gain; dizziness; irritability; stomach ache.

Less common side effects may include:

trouble breathing; increased need to urinate; noisy breathing; discomfort in the chest; Chest pain; irregular heartbeat; urinate more than usual; stun cough; Fainting; strong heartbeat; Mental depression; chest tightness.

Pregnancy and lactation

There are no well-conducted studies in women to determine infant risk when using this alpha2A-adrenergic receptor agonist during pregnancy. If you are pregnant or if you plan to become pregnant, weigh the potential benefits against the potential risks before you take it.

Also, it is not known exactly if this medicine passes into breast milk and harms the baby. Contact your doctor if you plan to breastfeed while using this alpha2A adrenergic receptor agonist.

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Contraindications

Before taking this alpha2A-adrenergic receptor agonist, tell your doctor if you have:

heart block; liver disease; heart disease; coronary artery disease; kidney disease; career; low blood pressure.

Alcohol

Avoid consuming alcoholic beverages during treatment with this medication since alcohol can increase blood sugar levels and the effects of the drug. In addition, this medication can substantially reduce your tolerance to alcohol.

Drug interactions

You may interact negatively with other medications, especially:

Benadryl (diphenhydramine); Abilify (aripiprazole); Concerta (methylphenidate); Adderall (amphetamine / dextroamphetamine); Focalin XR (dexmethylphenidate); Adderall XR (amphetamine / dextroamphetamine); Lamictal (lamotrigine); aspirin; invocana; Lyrica (pregabalin); clonidine; methylphenidate; codeine; Motrin (ibuprofen); fish oil (omega-3 polyunsaturated fatty acids); Prozac (fluoxetine); Focalin (dexmethylphenidate); MiraLax (polyethylene glycol 3350); melatonin; Lexapro (escitalopram).

Intuniv

It is the brand name of a medication called guanfacine that belongs to a group of drugs called centrally acting alpha 2A adrenergic receptor agonists.

Mechanism of action

The medication works by affecting the receptors in the brain in a way that helps the patient deal with the symptoms of attention deficit hyperactivity disorder, such as: hyperactivity, emotional sensitivity and social aggression.

In addition, it works somewhat less than stimulants, such as Adderall and Ritalin, and something more than traditional non-stimulants, such as Strattera. It may be useful for the estimated 25 to 30 percent of children with attention deficit hyperactivity disorder who do not benefit from stimulant medications.

More importantly, unlike other medications for attention deficit hyperactivity disorder, it is said that this alpha 2A adrenergic receptor agonist is safer, since it is not a central nervous system stimulant medication.

Applications

It is used to treat attention deficit hyperactivity disorder in children who are at least 6 years old. The medication must be used as part of a comprehensive treatment program that generally includes educational, psychological and social therapy.

In addition, it is used to treat high blood pressure. Occasionally it is given together with other medications for blood pressure.

Dosage

It is usually administered anywhere from 1-4mg per day. A dose lasts 12 hours, however, it may have some effect up to 24 hours.

Notes – This medication is in the form of a pill, however, unlike other medications for attention deficit hyperactivity disorder, it can not be chewed, crushed or broken and must be swallowed completely.

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Its effectiveness and safety in children under 6 years have not been established. Therefore, do not give this medication to a child under 6 years of age.

Side effects and precautions

Common side effects may include:

dry mouth; mild drowsiness, slow heartbeat, mild dizziness, vomiting, irritability.

Rare side effects may include:

weakness; dry mouth; stomach ache; constipation; nausea; low blood pressure; hallucinations; difficulty to sleep; a feeling of dizziness as if he could faint; fatigue; rapid heartbeat; sedation; Chest pain.

Drug interactions

It can affect how other medications work, and other medications can affect the way this alpha 2A adrenergic receptor agonist works. Tell your health care provider if you take:

antipsychotics; ketoconazole; barbiturates; benzodiazepines; sedative medications for high blood pressure; valproic acid; Medications that can affect the enzymatic metabolism.

Pregnancy and lactation

It is not known exactly if this medicine passes into breast milk or if it could adversely affect a breastfeeding baby. Tell your healthcare provider if you are breast-feeding a baby.

Belongs to the pregnancy category B of the FDA. This means that this medication is not expected to be harmful to the fetus. Tell your healthcare provider if you are pregnant or plan to become pregnant during treatment with this alpha 2A adrenergic receptor agonist.

Contraindications

To make sure you can take this medication safely, tell your healthcare provider if you have any of these other conditions:

kidney disease; heart block; liver disease; heart disease ; if you have recently had a heart attack; low blood pressure; a history of apoplexy; coronary artery disease.

Alcohol

Avoid drinking alcohol while taking this medication, as alcohol may increase the risk of side effects, especially drowsiness.

Bottom line – Guanfacine vs Intuniv

Guanfacina is a? 2-adrenergic agonist used (alone or in combination with other medications) to treat hypertension. It can also be prescribed, alone or with other medications, for people with ADHD.

Intuniv (guanfacine active ingredient) is a non-stimulant treatment for ADHD. Actually, it is a long-acting form of guanfacine.

Referenceshttp://www.ema.europa.eu/docs/en_GB/document_library/Presentation/2016/02/WC50http://www.ajmc.com/newsroom/positive-results-from-phase-3-study-of-intunivhttps://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/Development

Guanfacine vs Intuniv – Comparison of uses and side effects, Source: https://www.yourhealthremedy.com/health-tips/guanfacine-vs-intuniv/

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