Glipizide vs Januvia – Comparison of uses and side effects

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Glipizide vs Januvia - Comparison of uses and side effects of diabetes

Sunlipizide

It is the generic version of the brand-name drug Glucotrol. It belongs to a group of medicines called sulfonylureas. It helps lower blood sugar (glucose) levels by making the pancreas secrete insulin.

Applications

This medication is used to treat type 2 diabetes mellitus by helping to control glucose (sugar) levels in the blood.

Type 2 diabetes is a chronic condition that affects the way your body metabolizes sugar, the most important source of fuel in your body.

Common symptoms of type 2 diabetes mellitus may include:

increased thirst; frequent urination; loss of consciousness; headaches increased hunger; blurry vision; dry mouth; fatigue (feeling tired); Unexplained weight loss

This prescription medication is sometimes used along with other antidiabetic medications to achieve better control of high blood sugar (glucose) levels.

Important note – this medicine does not cure type 2 diabetes

Dosage

The usual recommended initial dose is 5 mg once a day, administered before breakfast. People with liver disease can start with 2.5 mg.

Contraindications

To make sure this prescription medication is safe for you, tell your healthcare professional:

if you are deficient in porphyria or glucose 6-phosphate dehydrogenase; if you have ever had an allergic reaction to any type of medication; if you have kidney problems; if you are breast-feeding a baby; if you have liver problems; if you are pregnant or plan to become pregnant; if you have problems with your suprarenal pituitary glands; If you are taking other medications that are available to buy with a prescription, over-the-counter medications, as well as complementary medications and herbs.

Side effects and precautions

Common side effects may include:

Diarrhea; redness of the skin, rash or itching; constipation; Mild nausea; dizziness; drowsiness.

Less common side effects may include:

feeling tired or out of breath; Confusion; vomiting elevated cardio rhythm; severe nausea a feeling that you may pass out; pale skin; sweating or thirst; clay-colored stools; bleeding from the gums; upper stomach pain; nosebleeds; dark urine; fast or strong heartbeat; a throbbing headache; fever; yellowing of the skin or eyes; loss of appetite

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Alcoholalcohol

Avoid drinking alcoholic beverages while taking this medication, as drinking alcohol can increase the risk of serious side effects.

Pregnancy and lactation

This medicine seems to be safe during pregnancy. To be safe, tell your doctor if you are pregnant or plan to become pregnant before taking this medicine.

It is not known exactly if this medicine passes into breast milk or if it could adversely affect a breast-fed baby. Tell your health care provider that you are breast-feeding a baby before taking this medicine.

Drug interactionsdrug pills

You may interact negatively with other medications, especially:

Byetta (exenatide); Aleve (naproxen); lisinopril; furosemide; amlodipine; metoprolol; glimepiride; aspirin; Lantus (insulin glargine); hydrochlorothiazide; Low-potency aspirin (aspirin); levothyroxine; insulin; atorvastatin; simvastatin; stribild; Lipitor (atorvastatin); Bydureon (exenatide); glyburide; losartan carvedilol; Trulicity (dulaglutide); metformin; Crestor (rosuvastatin); gabapentin; Genvoya; Omeprazole

Januvia

It is the brand name of a medicine called sitagliptin, which belongs to the group of medicines for type 2 diabetes known as DPP-4 inhibitors.

Mechanism of action

It works by regulating the levels of insulin produced by the human body after eating.

This medicine is manufactured by Merck & Co, one of the largest pharmaceutical companies in the world. The FDA of the United States originally approved this medicine in 2006.

Applications

Is used for treatment of diabetes mellitus. In addition, it can be taken in combination with other diabetes medications to lower blood glucose levels.

Dosage

The normal recommended dose It is 100 mg orally, once a day.

Note – It is important to take this medication for type 2 diabetes exactly as prescribed by your healthcare professional.

Side effects and precautions

Common side effects may include:

Muscle pain; constipation; a sore throat Diarrhea; congested nose stomach pain; Headaches Back pain; nausea.

Less common side effects It can include:

vomiting feeling short of breath; unexplained weight gain; a sore throat urinating less than usual; fever; fast heart rate; swelling of your face or tongue; loss of appetite; burning in your eyes; Severe pain in the upper part of the stomach that usually extends to the back.

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Contraindications

Before using this medication for type 2 diabetes, tell your healthcare professional if you have:

gallstones an allergic reaction to any type of medication; pancreatitis; past or present kidney problems; very high levels of triglycerides; diabetic ketoacidosis, a condition that occurs when ketones accumulate in the body; Diabetes type 1.

Drug interactions

You may interact negatively with other medications, especially:

Byetta (exenatide); Aleve (naproxen); furosemide; amlodipine; glimepiride; aspirin; hydrochlorothiazide; Low-potency aspirin (aspirin); insulin; atorvastatin; Lipitor (atorvastatin); Bydureon (exenatide); losartan carvedilol; metformin; Crestor (rosuvastatin); Omeprazole; gabapentin; odefsey; Trulicity (dulaglutide); glyburide; simvastatin; Lantus (insulin glargine); metoprolol; lisinopril; levothyroxine

Alcohol

Alcohol can affect your blood glucose (sugar) levels. Do not drink alcohol while taking this medication without first checking with your health care provider.

Pregnancy and lactation

It is not known exactly if this medicine passes into breast milk or if it could adversely affect a breast-fed baby. Tell your health care provider that you are breast-feeding a baby before taking this medicine.

This medicine seems to be safe during pregnancy. To be safe, tell your doctor if you are pregnant or plan to become pregnant before taking this medicine.

Baseline – Glipizide vs Januvia

Glipizide (brand name – Glucotrol) belongs to a class of drugs called sulfonylureas, which act by stimulating the release of insulin from the pancreas.

Januvia (active ingredient – sitagliptin) is an inhibitor of DPP-4 that helps lower blood sugar (glucose) levels. The usual recommended dose is 100 mg orally once a day.

According to a 2013 study, both drugs provided similar efficacy in reducing A1C in people with type 2 diabetes mellitus and chronic renal failure. However, sitagliptin (Januvia) was generally well tolerated, with a lower risk of hypoglycaemia, compared with glipizide.

Referenceshttp://care.diabetesjournals.org/content/36/5/1304http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121553http://www.pfizer.com/files/products/uspi_glipizide_er.pdf

Glipizide vs Januvia – Comparison of uses and side effects, Source: https://www.yourhealthremedy.com/health-tips/glipizide-vs-januvia/

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