It is the brand name of a medicine called sodium hyaluronate (injection). It is a sterile product, similar to a gel, that contains hyaluronan (obtained from bacterial cells and dissolved in a sterile saline solution).
This injection helps to lubricate the joint, which leads to greater flexibility and mobility of the treated joint, therefore, reducing pain in the affected joint.
It is usually used to relieve joint pain caused by medically diagnosed osteoarthritis ("wear out" arthritis of the knee joint or other synovial joints).
Osteoarthritis (OA) is the most common form of arthritis. Actually, it is a degenerative joint disease that affects the cartilage at the end of the bones.
An estimated 27 million people in the United States have OA, and the knee is one of the most affected areas, according to the Arthritis Foundation. Statistically, most individuals with osteoarthritis are 45 years old, with more women having osteoarthritis than men.
The main symptoms of OA of the knee are:
mild swelling (caused by extra fluid in the joint); hard swellings and inflammation (caused by osteophytes); the muscles around the joint looked thin or wasted; A grinding sensation when you move the joint; the knees bent and bent; rigidity (especially after rest, this usually decreases after a minute or more as you move); the knee does not move as freely or as far as normal; pain (especially when the knee is moving or at the end of the day).
Note: This injection is usually given after other OA medications have been tried without successful treatment of the symptoms.
For at least 48 hours after receiving the injection, avoid activities with weights or standing for more than 60 minutes in a row, as well as high-impact sports such as tennis, soccer or running.
Mechanism of action
It works similarly to synovial fluid (which protects the knee from injuries and shocks) due to the presence of sodium hyaluronate as an active ingredient. Therefore, it gives relief from knee pain for up to 180 days.
The usual recommended dose is 2 ml injected into the affected knee at 3-week intervals, for a total of 3 injections. For the optimal effect, all 3 injections should be administered.
Tips: Do not use disinfectants for skin preparation containing quaternary ammonium salts (also called quats). In addition, this medication should not be administered through a needle previously used with medical solutions containing BZK (benzalkonium chloride). Store the medication in the original package at 2 ° -25 ° C (36 ° -77 ° F). Do not freeze.
Side effects and precautions
Common side effects may include:
stomach ache; pain where the medicine was injected; Muscle pain; nausea; headaches numbness or tingling sensation; difficulty walking a sore throat pain in the joints; sneezing back pain; irritation of the skin around the knee; feeling of tiredness, runny or stuffy nose.
Rare side effects It can include:
Confusion; anxiety; severe pain around the knee after the injection; heavy feeling chills or shakes; perspiration; fast heart rate.
To make sure this injection is safe for you, inform your health care Provider of all your medical conditions. Especially tell your health care provider if:
take another medicines including herbal supplements, prescription and over-the-counter medications, and vitamins; have a skin disease in the area where the injection will be given; are allergic to bird products, such as eggs, feathers or poultry; They are allergic to any type of medication.
Pregnancy and breastfeeding
Because this injection has not been proven in pregnant or lactating women, consult your doctor before using.
Is the brand of a medicine called Hylan g-f 20 that belongs to the group of medicines known as synovial fluid replacements.
The medication is made of a natural substance called hyaluronic acid. HA is found in rooster combs and helps cushion and lubricate joints.
This synovial fluid replacement works by imitating the body's own synovial fluid (a viscous fluid found in the cavities of the synovial joints). Pain relief can last up to 6 to 12 months.
The Food and Drug Administration of the United States originally approved it in 1997.
It is usually used to relieve the symptoms of osteoarthritis (the most common form of degenerative joint disease) in the joints of the ankle, hip, shoulder and knee.
It is injected directly into the knee joint by a doctor. It is usually given once a week for 3 weeks. It may take a few weeks or even a few months to feel the full effect.
Side effects and Precautions
Common side effects may include:
difficulty walking, heat, pain or swelling where the medicine was injected; a prickly feeling on the skin; Muscle pain; dizziness; irritation of the skin around the knee; nausea; Headaches; cold; fever.
Rare side effects may include:
acne; Facial nose; Itch; redness of the face.
To make sure this medication is safe for you, tell your health care provider if you have:
an allergy to feathers, birds or egg products; circulation problems in the legs; high levels of LDL and total cholesterol; blood clots
Euflexxa vs. Synvisc: What synovial fluid replacement is better?
A 2016 study that was carried out in the Department of Orthopedics and Rehabilitation, New York, USA. UU., Which compared the replacements of synovial fluids investigated, established that Euflexxa had the most favorable cost-utility ratio in comparison with all other products.
Euflexxa vs Synvisc – Compare the differences between side effects and uses, Source: https://www.yourhealthremedy.com/health-tips/euflexxa-vs-synvisc/
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