Clonazolam vs Clonazepam – Comparison of uses and side effects

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Clonazolam vs Clonazepam - Comparison of uses and side effects

Clonazolam

Clonazolam is a new depressant substance of the chemical class benzodiazepine. It works by interacting with a specific subset of GABA-A receptors in the brain. This increases the activity of the neurotransmitter – GABA.

This drug was first synthesized in the early 1970s by scientists from The Upjohn Company.

Applications

Due to its sedative and relaxing effects, this medicine is a very effective relaxant. In addition, it is used to treat epilepsy, but it can also be used to help people who have trouble sleeping.

Dosage

Strong – 400 – 500 g (0.4 – 0.5 mg)
Common: 250 – 400 g (0.25 – 0.4 mg)
Light – 100 – 250 g (0.1 – 0.25 mg)

Its effects last around 10 hours. The total tolerance is reached within a couple of days of continuous use.

Side effects Y Precautions

Common side effects may include:

lack of inhibition; possible suicidal tendencies; depression; fatigue; dizziness; irritability; weakness; Confusion; amnesia; disorientation

Rare side effects It can include:

Vertigo; blood disorders; increased anxiety impaired cognition; incrise of cardiac frecuency; empowerment of dreams; suppression of motivation; delusions; greater libido; deceleration of thought.

Addiction

Some people may experience mild euphoria after taking this benzodiazepine. This feeling is extremely gratifying and pleasing to the user.

This is why this drug has a high dependency rate. Actually, about fifty percent of people who are prescribed are becoming addicted to it.

Also, the best way to avoid withdrawal symptoms is to reduce the dose gradually, preferably under the supervision of your doctor.

Alcohol

Do not consume alcohol while taking this medication, as alcohol increases the activity of the inhibitory neurotransmitter gamma-aminobutyric acid and decreases the activity of excitatory neurotransmitters, such as – NMDA.

Drug interactions

You may interact negatively with other medications, especially:

muscle relaxants, sedatives and medications used to sleep; monoamine oxidase inhibitors; medications used to treat fungal infections, such as ketoconazole (Nizoral); phenothiazines (medicines used for serious mental illness); butatrans; anticonvulsant drugs, such as phenytoin (Dilantin) and valproic acid (Depakene); some medications for the heart, such as – metoprolol (Lopressor) and digoxin (Lanoxin); medications used to treat Parkinson's disease, such as levodopa (Larodopa, Sinemet); medications used to treat heartburn, such as ranitidine (Zantac) and cimetidine (Tagamet); narcotic analgesics and barbiturates; cough and cold medicines that contain antihistamines; medications used for anxiety, such as fluoxetine (Prozac).

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Pregnancy and lactation

Before taking this medication, tell your healthcare provider if you are pregnant, as it is not safe to use during pregnancy. In addition, it passes into breast milk and adversely affects the baby, therefore, you should not breast-feed while taking this medication.

Clonazepam

It is the generic name for a brand name drug called Klonopin, a type of medicine called benzodiazepine. It acts on nerve cells in the brain.

The US Food and Drug Administration UU It was originally approved in 1975 for the pharmaceutical company Roche.

Applications

This benzodiazepine is used for the treatment of:

post-traumatic stress disorder (PTSD); anxiety disorders; mania; social phobia; epilepsy; Panic disorders

Dosage

The usual recommended dose for panic disorder is 1.0 mg per day. In addition, the medication is usually used together with fluoxetine.

The maximum recommended dose is 4 mg per day.

Side effects and precautions

Common side effects may include:

increase in saliva; dizziness; loss of interest in sex; Confusion; memory loss; muscle pains; nervousness; frequent urination; constipation; blurry vision; decreased appetite; congestion or upper respiratory infection; depression; fatigue.

Rare side effects may include:

Chest pain; severe rash or urticaria; impaired motor function; difficulty breathing; psychosis; swelling of the lips, face or tongue; worsening of depression; mental confusion; seizures personality changes; Hepatic injury; thoughts of suicide aggression; impulsiveness and reckless behavior; lack of motivation.

Addiction

Unlike other similar medications, clonazepam is less likely to promote long-term dependence.

However, when a person stops taking this medication abruptly, some withdrawal symptoms may appear. Therefore, the medication should be suspended gradually decreasing the dose in 0.125 mg every three days.

Drug interactions

It can interact negatively with many other medications that work in your brain and nervous system, including:

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muscle relaxants; anti-anxiety medications; elegard; medications to treat depression, including tricyclic antidepressants, monoamine oxidase inhibitors, and certain selective serotonin reuptake inhibitors; narcotic pain medications; medications used to treat seizures, such as phenobarbital (Luminal, Solfoton), carbamazepine (Tegretol), and phenytoin (Dilantin); the irregular heartbeat drug Amiodarone (Cordarone, pacerone); medicines used to treat mental illnesses, such as thioxanthenes, phenothiazines and butyrophenones; Grass of San Juan; sleeping pills; temazepam; cimetidine (Tagamet); medications used to treat fungal infections, such as ketoconazole (Nizoral) and itraconazole (Sporanox); Drugs against HIV / AIDS, such as nelfinavir (Viracept), indinavir (Crixivan) and ritonavir (Norvir, Kaletra); calcium channel blockers, such as – verapamil (Calan, Isoptin, Verelan) and diltiazem (Cardizem, Dilacor, Tiazac); certain antibiotics, such as erythromycin (erythrin) and clarithromycin (Biaxin, Prevpac).

Pregnancy and lactation

It is not safe to take this medicine while breast-feeding a baby. Therefore, talk to your healthcare provider about other options if you are breastfeeding.

In addition, it is dangerous to take it during pregnancy, as there is strong evidence that this medication may increase the risk of birth defects.

Bottom line – Clonazolam vs. Clonazepam

Clonazolam is a medication that belongs to the class of benzodiazepines. These medications are a class of psychoactive medications that affect the neurotransmitter called gamma-aminobutyric acid. It is a drug with rapid onset of action and symptomatic relaxation. Your initial reaction takes around 20 to 60 minutes.

Clonazepam (brand name) Klonopin) is a medication that works by acting on receptors in the brain called GABA receptors. Gamma-aminobutyric acid intervenes in the transmission of messages between nerve cells and acts as a natural agent that calms the nerves. Unlike other benzodiazepines, this medication can trigger depressive episodes in people with a history of depression.

According to the studies, clonazepam can be used better in functional situations, while clonazolam seems to be more sedative and more likely to produce recreational effects.

Referenceshttps://www.ncbi.nlm.nih.gov/pubmed/27685473https://www.ncbi.nlm.nih.gov/pubmed/27121429https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857865/

Clonazolam vs Clonazepam – Comparison of uses and side effects, Source: https://www.yourhealthremedy.com/health-tips/clonazolam-vs-clonazepam/

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