Briviact vs Keppra for seizures – Differences and side effects

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Briviact vs Keppra for seizures - Differences and side effects

Briviact

It is the brand name of a medicine called brivaracetam, which belongs to a group of medicines known as antiepileptic drugs.

Mechanism of action

It works by reducing the frequency of seizures.

Applications

This prescription medication is used to treat partial-onset seizures in people over 16 years of age with epilepsy, a disorder of the central nervous system in which brain activity becomes abnormal.

Epilepsy is a fairly common neurological disorder that affects more than 3 million people in the United States and an estimated 65 million people worldwide.

Repeated seizures are the most common symptom of epilepsy. Other symptoms may also include:

the person becomes rigid; short blackouts the victim becomes fearful for no reason; confused memory Peculiar changes in the senses; Sudden blinking buds without apparent stimuli; the victim seems dazed and unable to communicate; a seizure without temperature; for a short period, the individual does not answer the questions; the person suddenly falls down without a clear reason; Repetitive movements that seem inappropriate; sudden attacks of chewing; intermittent fainting, during which intestinal control is lost.

Dosage

The usual recommended dose is 50 mg twice a day. The maximum recommended dose is 200 mg per day.

Side effects and precautions

Common side effects may include:

feeling tired; drowsiness; vomiting nausea; dizziness.

Rare side effects may include:

unusual changes in mood or behavior; severe drowsiness hallucinations (seeing or hearing things that are not real); unusual thoughts loss of balance; a feeling that you can faint.

Contraindications

Before taking this antiepileptic, tell your healthcare provider if you have:

drug addiction; alcoholism; liver disease; suicidal thoughts; Depression or mood disorder.

AlcoholAlcohol

Avoid drinking alcoholic beverages while taking this antiepileptic since alcohol consumption can substantially increase the risk of serious side effects.

Drug interactionsmedicines pills medications

You may interact negatively with other medications, especially:

lamotrigine; atorvastatin; levothyroxine; clonazepam; Lyrica (pregabalin); Cymbalta (duloxetine); Topamax (topiramate); Keppra (levetiracetam); topiramate; adzenys; Klonopin (clonazepam); Vimpat (lacosamide); Lamictal (lamotrigine); Zofran (ondansetron); levetiracetam; trazodone; opsumit; Lomotil (atropine / diphenoxylate); Singulair (montelukast); ProAir HFA (albuterol); Lorazepam

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Pregnancy and lactation

There are no well-conducted studies to determine if this antiepileptic is safe to use during pregnancy. If you are pregnant, your name may appear in a pregnancy registry. Tell your health care provider that you are pregnant or plan to become pregnant before using this medication.

It is not known exactly if this antiepileptic passes into human breast milk or if it could adversely affect a breastfed baby. Tell your health care provider that you are breast-feeding a baby before using this antiepileptic.

Keppra

Image credit: https://commons.wikimedia.org/wiki/File:UCB_Keppra_1000mg.jpg

It is the mark of a drug called levetiracetam, which belongs to a group of medicines known as anticonvulsants.

Mechanism of action

It works by stabilizing the electrical activity in the brain.

Applications

Is Medical prescription It is used to treat epilepsy, sometimes in combination with other medications.

Dosage

Start the treatment with a daily dose of 1000 mg / day, administered in doses of twice a day (500 mg twice a day). Additional increments of doses (1000 mg / day additional every 2 weeks) can be administered up to a maximum recommended daily dose of 3000 mg.

The effect of this anticonvulsant lasts around 18 to 24 hours. Its maximum effect can be observed within about 4 hours for an extended release tablet and within one hour for an immediate release tablet.

Pregnancy and lactation

It is not known exactly if this anticonvulsant passes into human breast milk or if it could adversely affect a breastfed baby. Tell your health care provider that you are breast-feeding a baby before using this anticonvulsant.

There are no well-done studies to determine if this medicine It is safe to use during pregnancy. Tell your health care provider that you are pregnant or planning to become pregnant before using this anticonvulsant.

Side effects and precautions

Common side effects It can include:

infection; become dizzy aggressive; weakness; feeling tired; nasal congestion; decreased appetite; drowsiness; irritability.

Less common side effects may include:

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painful sores in the mouth; muscular weakness; skin sores; loss of balance; pain when swallowing; swollen gums; severe tingling unusual changes in behavior; problems walking; bruising easily; Confusion; feel very weak; extreme drowsiness hallucinations; difficulty breathing.

Alcohol

Avoid drinking alcoholic beverages while taking this anticonvulsant, since alcohol consumption can substantially increase the risk of serious side effects.

Drug interactions

Let your health care provider know if you are taking something that may make you sleepy, in particular:

muscle relaxants; diphenhydramine (Sominex, Banophen); narcotic analgesics, such as – codeine; Diazepam (Valium); Symbicort; sleeping medications, such as – alprazolam (Xanax); Zolpidem (Edluar); antihistamines, such as cetirizine (Alleroff).

Contraindications

To make sure this anticonvulsant is safe for you, tell your doctor if you have:

kidney disease (or if you are on dialysis); a history of mental illness; a story of suicidal thoughts; Depression or other mood problems

Bottom line – Briviact vs Keppra

Briviact (active ingredient – brivaracetam) is an antiepileptic drug used to treat partial onset seizures in people with epilepsy who are at least 16 years old.

Keppra (active ingredient – levetiracetam) is an anticonvulsant medication used to prevent and treat seizures. It belongs to a group of medicines called anticonvulsants.

Both drugs target the 2A protein of the synaptic vesicle, however, it is observed that Briviact is more selective and has a higher affinity for this receptor than Keppra.

According to a 2014 study, people treated with Briviact 20, 50, 100 mg per day were compared with a placebo group. Patients treated with brivaracetam at a dose of 50 mg per day experienced a substantial reduction in the frequency of seizures compared to the placebo group.

Regarding its price, the average retail price of 60 tablets of Briviact 100 mg is $ 1,100, while the average retail price of 60 tablets of Keppra 500 mg is $ 220.

Referenceshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265234/http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines

Briviact vs Keppra for seizures – Differences and side effects, Source: https://www.yourhealthremedy.com/health-tips/briviact-vs-keppra/

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