Brexpiprazole vs Aripiprazole: What is the best antipsychotic for schizophrenia?

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Brexpiprazole vs Aripiprazole - What is the best antipsychotic for schizophrenia?

Brexpiprazole (sold under the brand name Rexulti) is an antipsychotic medication. In addition, it is known as a second generation antipsychotic (SGA).

This medication works by altering the activity of certain natural substances in the human brain, including the adrenergic receptors serotonin type 2, dopamine type 2 and alpha 2.

Rexulti was approved for the first time in 2015 by the Food and Drug Administration to treat schizophrenia.

Applications

It is usually used to treat the symptoms of schizophrenia. Currently, 20 antipsychotic medications are approved for clinical use in the United States, with Rexulti being one of the most recent medications available.

Schizophrenia is a debilitating chronic mental illness described by abnormal behaviors, disordered thoughts and antisocial behaviors. Risk factors for schizophrenia include:

drug abuse during adolescence and early adulthood; abnormalities of the autoimmune system; a father who is older in age; Family history of the disorder.

Schizophrenia is surprisingly common and affects 1 in 100 people in the world with more than 2.5 million adults in the United States who have schizophrenia. According to the data, approximately 3 out of 4 patients experience relapses and their signs and symptoms return or worsen.

The eeffectiveness of medications in the treatment of schizophrenia, it was evaluated in 1,310 participants in two 6-week clinical trials. It was shown to reduce the occurrence of signs and symptoms of schizophrenia compared to placebo.

In addition, this medication is used together with other medications to treat major depressive disorder (MDD) in adults. However, it is not approved by the FDA for the treatment of conduct disorders in older adults with dementia.

Dosage

the recommended dose to treat Schizophrenia is 2 mg to 4 mg once a day. The initial dose recommended as a complementary treatment for major depressive disorder is 0.5 mg or 1 mg once a day, orally.

Side effects

Common side effects may include:

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weight gain; Muscle pain; Back pain; tremors stomach ache; acne; restlessness; constipation; acidity; dry mouth; drowsiness; Diarrhea.

Rare side effects may include:

seizures neuroleptic malignant syndrome (Occurs in response to neuroleptics or antipsychotics).do medication); muscle problems that cause abnormal movement; allergic reactions, With symptoms that include: redness of the skin, especially around the mouth and pain in the chest; have suicidal thoughts, especially in patients 24 years old or younger; Diabetes mellitus type 2; granulocyte deficiency (a category of white blood cells); decrease in white blood cells (cells of the immune system); Decreased neutrophils (the most abundant type of granulocytes).

Because this medication can cause drowsiness, it is not recommended to use machinery, to drive a car, until you know it can work normally.

There are no clinical studies conducted on the safety of this medication during pregnancy, therefore, stay on the safe side and avoid it. Also, to be 100 percent sure that this medication is safe for you, tell your health care provider if you have:

difficulty swallowing; Diabetes mellitus type 2; cranial injury; Brain tumor; a history of convulsions; heart attack; liver disease; low white blood cell count; kidney disease; high or low blood pressure; heart disease; high triglycerides; High levels of LDL and total cholesterol.

Aripiprazole

It is the brand name of Abilify, a psychotropic drug that alters the brain's chemical activity by blocking nerve receptors in the brain for some neurotransmitters.

This medication is usually used to treat schizophrenia, depression, mania, autistic disorder, bipolar disorder (manic-depressive illness) and some irritable behavior disorders.

In 2002, Abilify was approved for the first time by the Food and Drug Administration to treat schizophrenia in adults and children over 13 years of age.

Applications

It is usually used to treat the symptoms of psychotic conditions, such as bipolar I disorder (manic depression) and schizophrenia.

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In addition, it is used to treat mood swings, irritability, aggression symptoms, tantrums and self-harm related to autistic disorder in children who are at least 6 years old.

Dosage

It comes in 3 forms to take orally: solution, tablets and tablets of oral disintegration. In addition, it is presented only as an injectable solution. given by a doctor.

Take this medication exactly as it is written on the label of your prescription or by your health care provider. Do not take less or more than prescribed by your health professional.

Side effects

Common side effects may include:

weight gain; nausea; anxiety; barf; restlessness and agitation; constipation; fatigue; headache; dizziness; problems sleeping; nasal congestion; mild upset stomach Increased appetite; drowsiness; difficulty swallowing; muscular stiffness; Uncontrolled movements

Rare side effects It can include:

signs of infection; convulsions malignant neuroleptic syndrome; expression of face mask; suicidal thoughts; Fainting; muscle spasms; shake.

Long-term use of this medication can lead to tardive dyskinesia (involuntary movements of the lips, jaw, and tongue), a potentially irreversible condition.

There is possible evidence of harm to the unborn baby, therefore, it is not recommended for pregnant women.

More importantly, it is not known precisely if this medication is safe in children under 10 years of age with bipolar disorder or in children under 13 years of age with schizophrenia.

Brexpiprazole vs Aripiprazole: What is the best antipsychotic for schizophrenia?

Brexpiprazole is a second generation antipsychotic especially produced to treat the symptoms of schizophrenia. On the other hand, aripiprazole has been used since 2002, however, it is produced to treat a range of mental conditions, such as bipolar disorder, depression, mania or autistic disorder. Both have similar side effects.

Referenceshttps://www.ncbi.nlm.nih.gov/pubmed/25882325https://www.sciencedirect.com/science/article/pii/S092099641630161Xhttps://www.sciencedirect.com/science/article/pii/S0920996415003461https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671949/

Brexpiprazole vs Aripiprazole: What is the best antipsychotic for schizophrenia? Source: https://www.yourhealthremedy.com/health-tips/brexpiprazole-vs-aripiprazole/

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