A team of scientists has discovered the mechanism that allows the virus to replicate. His study could open new therapeutic routes to treat not only cytomegalovirus, but also other viruses.
Human cytomegalovirus is one of the main causes of birth defects and failure in transplantation. As it has evolved over time, this virus from the herpes family has found a way to avoid the body's defense mechanisms that generally protect against viral infections. Until now, the scientists could not understand how he manages to do it. Normally, when a virus enters your cell, that cell blocks the virus's DNA and prevents it from taking any action. The virus must overcome this barrier to multiply effectively.
Cytomegalovirus does not simply inject its own DNA into a human cell. Instead, it transports its viral DNA to the cell along with proteins called PP71. After entering the cell, it releases these PP71 proteins, which allow the viral DNA to replicate and the infection to spread.
The researchers found that, while PP71 is still present in the cell, it activates another protein known as IE1. This happens within the first few hours of virus entry into the cell, which allows the IE1 protein to take over after PP71 dies and continues to create a new virus.
The first author of the new study, Noam Vardi, said: "We noticed that when the IE1 protein degrades slowly, as is often the case, the virus can replicate very efficiently. But if the protein breaks down faster, the virus can not multiply too. Then, we confirm that the virus needs the IE1 protein to replicate successfully. "
The new study could lead to a new therapeutic target to attack cytomegalovirus and other herpesviruses, such as the Epstein-Barr virus that causes mononucleosis and the herpes simplex virus 1 and 2 that produce most mouth ulcers and genital herpes. , concluded the study published in the magazine Procedures of the National Academy of Sciences.
At the beginning of the year, another investigation carried out in University of California had shown that low levels of cytomegalovirus had a significant impact on the populations of microbes and immune cells and on how the immune system responded to the influenza vaccine.
(With the entries of ANI)
Reference: https://www.thehealthsite.com/news/study-finds-a-new-way-to-attack-herpes-viruses-ai0818/, by Editorial Team