1. HLA B27 (human leukocyte antigen) is not a disease. It is a gene in your body.
2. A positive HLA B27 test does not mean you have a disease. If you look at the entire population, most people who carry this gene will not develop ankylosing spondylitis. The utility of the test depends on the context in which it is ordered. The history and the exam are really useful.
3. HLA-B27 is a normal genetic variant. HLA B27 can be positive in up to 8% of the normal population. If your HLA B27 test is positive, it is usually not necessary to do it again. It does not disappear even after treatment. The positivity of HLA B27 is associated with a variety of diseases such as ankylosing spondylitis, psoriasis, inflammatory bowel disease, reactive arthritis, etc.
4. About 80 to 90% of patients with ankylosing spondylitis test positive for HLA-B27.7. If you observe indiscriminately the entire population, only 10-15% of people with this HLA-B27 gene will end up developing ankylosing spondylitis or another type of spondyloarthritis.
5. The history suggesting inflammatory back pain should prompt a doctor to order the HLA-B27 test. In this context, a positive HLA B27 test is useful to make the diagnosis.
6. Keep in mind that a negative HLA-B27 test does not completely rule out the diagnosis of ankylosing spondylitis. About 10-20% of patients with proven ankylosing spondylitis will give a negative result for HLA B27. The treatment depends on the final diagnosis and the severity of the disease.
Read the full article "6 things you should know about the Hla B27 test" that Dr. Cravin Patil wrote on Practo.com here: https://www.practo.com/healthfeed/6-things-you-should-know – about-hla-b27-test-28895 / post
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